Dynamics of the emergence and establishment of a newly dominant genotype of Japanese encephalitis virus throughout Asia.

ABSTRACT:

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In recent years, genotype I (GI) of Japanese encephalitis virus (JEV) has displaced genotype III (GIII) as the dominant virus genotype throughout Asia. In this study, the largest collection of GIII and GI envelope gene-derived viral sequences assembled to date was used to reconstruct the spatiotemporal chronology of genotype displacement throughout Asia and to determine the evolutionary and epidemiological dynamics underlying this significant event. GI consists of two clades, GI-a and GI-b, with the latter being associated with displacement of GIII as the dominant JEV genotype throughout Asia in the 1990s. Phylogeographic analysis indicated that GI-a diverged in Thailand or Cambodia and has remained confined to tropical Asia, whereas GI-b diverged in Vietnam and then dis

SUBMITTER: Schuh AJ 

PROVIDER: S-EPMC3993778 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature