An air- and water-stable iodonium salt promoter for facile thioglycoside activation.

ABSTRACT: The air- and water-stable iodonium salt phenyl(trifluoroethyl)iodonium triflimide is shown to activate thioglycosides for glycosylation at room temperature. Both armed and disarmed thioglycosides rapidly undergo glycosylation in 68-97% yield. The reaction conditions are mild and do not require strict exclusion of air and moisture. The operational simplicity of the method should allow experimentalists with a limited synthetic background to construct glycosidic linkages.

SUBMITTER: Chu AH 

PROVIDER: S-EPMC3993783 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature