Aminodiols via stereocontrolled oxidation of methyleneaziridines.

ABSTRACT: A highly diastereoselective Ru-catalyzed oxidation/reduction sequence of bicyclic methyleneaziridines provides a facile route to complex 1-amino-2,3-diol motifs. The relative anti stereochemistry between the amine and the vicinal alcohol are proposed to result from 1,3-bischelation in the transition state by the C1 and C3 heteroatoms.

SUBMITTER: Rigoli JW 

PROVIDER: S-EPMC3993784 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature