Palladium-catalyzed α-arylation of benzylic phosphonates.

ABSTRACT: A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)2/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64-92%).

SUBMITTER: Montel S 

PROVIDER: S-EPMC3993846 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature