Direct access to functionalized azepanes by cross-coupling with α-halo eneformamides.

ABSTRACT: The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the coupling products were obtained.

SUBMITTER: Beng TK 

PROVIDER: S-EPMC3993866 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature