Ontology highlight
ABSTRACT:
SUBMITTER: Elsayed M
PROVIDER: S-EPMC3993926 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Elsayed Maha M Corrand Vincent V Kolhatkar Vidula V Xie Yuran Y Kim Na Hyung NH Kolhatkar Rohit R Merkel Olivia M OM
Biomacromolecules 20140304 4
Spermines are naturally abundant polyamines that partially condense nucleic acids and exhibit the proton-sponge effect in an acidic environment. However, spermines show a limited efficiency for transfecting nucleic acids because of their low molecular weight. Therefore, spermines need to be modified to be used as nonviral vectors for nucleic acids. Here, we synthesized linear bisspermine as well as a linear and dendritic tetraspermine with different molecular architectures. These oligospermines ...[more]