HD CAGnome: a search tool for huntingtin CAG repeat length-correlated genes.

ABSTRACT:

Background

The length of the huntingtin (HTT) CAG repeat is strongly correlated with both age at onset of Huntington's disease (HD) symptoms and age at death of HD patients. Dichotomous analysis comparing HD to controls is widely used to study the effects of HTT CAG repeat expansion. However, a potentially more powerful approach is a continuous analysis strategy that takes advantage of all of the different CAG lengths, to capture effects that are expected to be critical to HD pathogenesis.

Methodology/principal findings

We used continuous and dichotomous approaches to analyze microarray gene expression data from 107 human control and HD lymphoblastoid cell lines. Of all probes found to be significant in a continuous analysis by CAG length, only 21.4% were so identified by a

SUBMITTER: Galkina EI 

PROVIDER: S-EPMC3994101 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature