Analysis of protein-protein interaction network and functional modules on primary osteoporosis.

ABSTRACT:

Background

Primary osteoporosis is an age-related disease, and the main cause of this disease is the failure of bone homeostasis. Previous studies have shown that primary osteoporosis is associated with gene mutations.To explore the functional modules of the PPI (protein-protein interaction) network of differentially expressed genes (DEGs), and the related pathways participating in primary osteoporosis.

Methods

The gene expression profile of primary osteoporosis GSE35956 was downloaded from the GEO (Gene Expression Omnibus) database and included five MSC (mesenchymal stem cell) specimens of normal osseous tissue and five MSC specimens of osteoporosis. The DEGs between the two types of MSC specimens were identified by the samr package in R language. In addition, the functions

SUBMITTER: Li GL 

PROVIDER: S-EPMC3994448 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature