Ontology highlight
ABSTRACT:
SUBMITTER: Morfouace M
PROVIDER: S-EPMC3994669 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Cancer cell 20140327 4
We devised a high-throughput, cell-based assay to identify compounds to treat Group3 medulloblastoma (G3 MB). Mouse G3 MBs neurospheres were screened against a library of approximately 7,000 compounds including US Food and Drug Administration-approved drugs. We found that pemetrexed and gemcitabine preferentially inhibited G3 MB proliferation in vitro compared to control neurospheres and substantially inhibited G3 MB proliferation in vivo. When combined, these two drugs significantly increased s ...[more]