Expressional regulation of genes linked to immunity & programmed development in human early placental villi.

ABSTRACT:

Background & objectives

During 6 to 8 wk of gestation, human placental villi show a complex pattern of morphogenesis. There is however, no large scale gene expression study exploring the temporal pattern of the developmental molecular networks in placental villi during the early weeks of gestation. We evaluated the transcriptome profiling of humn placental villus samples obtained from fertile women with voluntarily terminated normal pregnancies between 6-8 wk of gestation.

Methods

Transcriptomic profiles of individual human placental villous samples from 25 women with normal pregnancies during 6 to 8 wk of gestation were examined using human whole genome expression arrays. Quantitative RT-PCR validation of copy numbers of transcripts for selected 15 genes and exploratory ana

SUBMITTER: Khan MA 

PROVIDER: S-EPMC3994729 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature