Protein (multi-)location prediction: using location inter-dependencies in a probabilistic framework.

ABSTRACT:

Motivation

Knowing the location of a protein within the cell is important for understanding its function, role in biological processes, and potential use as a drug target. Much progress has been made in developing computational methods that predict single locations for proteins. Most such methods are based on the over-simplifying assumption that proteins localize to a single location. However, it has been shown that proteins localize to multiple locations. While a few recent systems attempt to predict multiple locations of proteins, their performance leaves much room for improvement. Moreover, they typically treat locations as independent and do not attempt to utilize possible inter-dependencies among locations. Our hypothesis is that directly incorporating inter-dependencies among

SUBMITTER: Simha R 

PROVIDER: S-EPMC3994749 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature