Can transcriptomics provide insight into the chemopreventive mechanisms of complex mixtures of phytochemicals in humans?

ABSTRACT: Blueberries contain relatively large amounts of different phytochemicals, which are suggested to have chemopreventive properties, but little information is available on the underlying molecular modes of action. This study investigates whole genome gene expression changes in lymphocytes of 143 humans after a 4-week blueberry-apple juice dietary intervention. Differentially expressed genes and genes correlating with the extent of antioxidant protection were identified in four subgroups. The magnitude of the preventive effect after the intervention differed between these four subgroups. Furthermore, subjects in two groups carried genetic polymorphisms that were previously found to influence the chemopreventive response. Pathway analysis of the identified genes showed strong but complex gene e

SUBMITTER: van Breda SG 

PROVIDER: S-EPMC3994912 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature