Effect of probenecid on pharmacokinetics and tolerability of olmesartan in healthy chinese volunteers.

ABSTRACT:

Background

Olmesartan is an angiotensin II receptor antagonist and is effective and well tolerated in the treatment of arterial hypertension. Probenecid is a well-established hypouricemic agent for the treatment of hyperuricemia and gout.

Objective

The goal of this study was to examine the impact of coadministration of probenecid on the pharmacokinetic parameters and tolerability of olmesartan in healthy volunteers.

Methods

In a randomized, open-label, 2-way crossover study, 12 volunteers received 2 oral treatments (olmesartan alone or olmesartan plus probenecid) separated by 4 days. Blood samples were obtained for a 48-hour pharmacokinetic evaluation after drug administration. Tolerability was assessed by monitoring vital signs and laboratory tests before and after a

SUBMITTER: Li KY 

PROVIDER: S-EPMC3994918 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature