Frequency of morning ketosis after overnight insulin suspension using an automated nocturnal predictive low glucose suspend system.

ABSTRACT:

Objective

To assess the effect of overnight insulin pump suspension in an automated predictive low glucose suspend system on morning blood glucose and ketone levels in an attempt to determine whether routine measurement of ketone levels is useful when a closed-loop system that suspends insulin delivery overnight is being used.

Research design and methods

Data from an in-home randomized trial of 45 individuals with type 1 diabetes (age range 15-45 years) were analyzed, evaluating an automated predictive low glucose pump suspension system in which blood glucose, blood ketone, and urine ketone levels were measured on 1,954 mornings.

Results

One or more pump suspensions occurred during 744 of the 977 intervention nights (76%). The morning blood ketone level was ≥0.6 mmol/

SUBMITTER: Beck RW 

PROVIDER: S-EPMC3994933 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature