Automated hippocampal segmentation in patients with epilepsy: available free online.

ABSTRACT:

Purpose

Hippocampal sclerosis, a common cause of refractory focal epilepsy, requires hippocampal volumetry for accurate diagnosis and surgical planning. Manual segmentation is time-consuming and subject to interrater/intrarater variability. Automated algorithms perform poorly in patients with temporal lobe epilepsy. We validate and make freely available online a novel automated method.

Methods

Manual hippocampal segmentation was performed on 876, 3T MRI scans and 202, 1.5T scans. A template database of 400 high-quality manual segmentations was used to perform automated segmentation of all scans with a multi-atlas-based segmentation propagation method adapted to perform label fusion based on local similarity to ensure accurate segmentation regardless of pathology. Agreement b

SUBMITTER: Winston GP 

PROVIDER: S-EPMC3995014 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature