Dampened hippocampal oscillations and enhanced spindle activity in an asymptomatic model of developmental cortical malformations.

ABSTRACT: Developmental cortical malformations comprise a large spectrum of histopathological brain abnormalities and syndromes. Their genetic, developmental and clinical complexity suggests they should be better understood in terms of the complementary action of independently timed perturbations (i.e., the multiple-hit hypothesis). However, understanding the underlying biological processes remains puzzling. Here we induced developmental cortical malformations in offspring, after intraventricular injection of methylazoxymethanol (MAM) in utero in mice. We combined extensive histological and electrophysiological studies to characterize the model. We found that MAM injections at E14 and E15 induced a range of cortical and hippocampal malformations resembling histological alterations of specific geneti

SUBMITTER: Cid E 

PROVIDER: S-EPMC3995045 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature