An Interaction Library for the FcεRI Signaling Network.

ABSTRACT: Antigen receptors play a central role in adaptive immune responses. Although the molecular networks associated with these receptors have been extensively studied, we currently lack a systems-level understanding of how combinations of non-covalent interactions and post-translational modifications are regulated during signaling to impact cellular decision-making. To fill this knowledge gap, it will be necessary to formalize and piece together information about individual molecular mechanisms to form large-scale computational models of signaling networks. To this end, we have developed an interaction library for signaling by the high-affinity IgE receptor, FcεRI. The library consists of executable rules for protein-protein and protein-lipid interactions. This library extends earlier models fo

SUBMITTER: Chylek LA 

PROVIDER: S-EPMC3995055 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature