The role of bacterial protein tyrosine phosphatases in the regulation of the biosynthesis of secreted polysaccharides.

ABSTRACT:

Significance

Tyrosine phosphorylation and associated protein tyrosine phosphatases are gaining prominence as critical mechanisms in the regulation of fundamental processes in a wide variety of bacteria. In particular, these phosphatases have been associated with the control of the biosynthesis of capsular polysaccharides and extracellular polysaccharides, critically important virulence factors for bacteria.

Recent advances

Deletion and overexpression of the phosphatases result in altered polysaccharide biosynthesis in a range of bacteria. The recent structures of associated auto-phosphorylating tyrosine kinases have suggested that the phosphatases may be critical for the cycling of the kinases between monomers and higher order oligomers.

Critical issues

Additional sub

SUBMITTER: Standish AJ 

PROVIDER: S-EPMC3995119 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature