Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions.

ABSTRACT: Genes that alter disease risk only in combination with certain environmental exposures may not be detected in genetic association analysis. By using methods accounting for gene-environment (G × E) interaction, we aimed to identify novel genetic loci associated with breast cancer risk. Up to 34,475 cases and 34,786 controls of European ancestry from up to 23 studies in the Breast Cancer Association Consortium were included. Overall, 71,527 single nucleotide polymorphisms (SNPs), enriched for association with breast cancer, were tested for interaction with 10 environmental risk factors using three recently proposed hybrid methods and a joint test of association and interaction. Analyses were adjusted for age, study, population stratification, and confounding factors as applicable. Three SNPs

SUBMITTER: Schoeps A 

PROVIDER: S-EPMC3995140 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature