Understanding how and why the Gene Ontology and its annotations evolve: the GO within UniProt.

ABSTRACT: The Gene Ontology Consortium (GOC) is a major bioinformatics project that provides structured controlled vocabularies to classify gene product function and location. GOC members create annotations to gene products using the Gene Ontology (GO) vocabularies, thus providing an extensive, publicly available resource. The GO and its annotations to gene products are now an integral part of functional analysis, and statistical tests using GO data are becoming routine for researchers to include when publishing functional information. While many helpful articles about the GOC are available, there are certain updates to the ontology and annotation sets that sometimes go unobserved. Here we describe some of the ways in which GO can change that should be carefully considered by all users of GO as they

SUBMITTER: Huntley RP 

PROVIDER: S-EPMC3995153 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature