Measuring respiratory symptoms in clinical trials of COPD: reliability and validity of a daily diary.

ABSTRACT:

Background

Although respiratory symptoms are characteristic features of COPD, there is no standardised method for quantifying their severity in stable disease.

Objective

To evaluate the EXACT-Respiratory Symptom (E-RS) measure, a daily diary comprising 11 of the 14 items in the Exacerbations of Chronic Pulmonary Disease Tool (EXACT).

Methods

Qualitative: patient focus group and interviews to address content validity. Quantitative: secondary data analyses to test reliability and validity.

Results

Qualitative: n=84; mean (SD) age 65 (10) years, FEV1 1.2(0.4) L; 44% male. Subject descriptions of their respiratory symptoms were consistent with E-RS content and structure. Quantitative: n=188; mean (SD) age 66 (10) years, FEV1 1.2(0.5) L; 50% male. Factor analysis (F

SUBMITTER: Leidy NK 

PROVIDER: S-EPMC3995276 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature