Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function.

ABSTRACT: In heart failure mitochondrial dysfunction is thought to be responsible for energy depletion and contractile dysfunction. The difficulties in procuring fresh left ventricular (LV) myocardium from humans for assessment of mitochondrial function have resulted in the reliance on surrogate markers of mitochondrial function and limited our understanding of cardiac energetics. We isolated mitochondria from fresh LV wall tissue of patients with heart failure and reduced systolic function undergoing heart transplant or left ventricular assist device placement, and compared their function to mitochondria isolated from the non-failing LV (NFLV) wall tissue with normal systolic function from patients with pulmonary hypertension undergoing heart-lung transplant. We performed detailed mitochondrial fun

SUBMITTER: Cordero-Reyes AM 

PROVIDER: S-EPMC3995348 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature