ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia.

ABSTRACT: In recent years considerable progress has been made in treatment strategies for chronic lymphocytic leukemia (CLL). However, the disease remains incurable because of the development of chemoresistance. Strategies to overcome resistance mechanisms are therefore highly needed. At least two mechanisms contribute to the development of resistance to drugs; acquired mutations resulting in a dysfunctional p53 response and shifts in the balance between apoptosis-regulating proteins. Platinum-based compounds have been successfully applied in relapsed lymphoma and recently also in high-risk CLL. In this study we investigated the efficacy and mechanism of action of cisplatinum (CDDP) in chemorefractory CLL. Independent of p53-functional status, CDDP acted synergistically with fludarabine (F-ara-A). T

SUBMITTER: Tonino SH 

PROVIDER: S-EPMC3995409 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature