Polymorphic patterns of the merozoite surface protein-3β in Korean isolates of Plasmodium vivax.

ABSTRACT:

Background

The merozoite surface protein-3β of Plasmodium vivax (PvMSP-3β) is one of the candidate antigens for blood stage malaria vaccine development. The polymorphisms in PvMSP-3β have been reported in certain P. vivax isolates. However, the diversity of PvMSP-3β throughout its global distribution has not been well understood. In this study, the genetic diversity and the effects of natural selection in PvMSP-3β among P. vivax Korean isolates were analysed.

Methods

Blood samples were collected from 95 patients with vivax malaria in Korea. The region flanking full-length PvMSP-3β was amplified by polymerase chain reaction and cloned into a TA cloning vector. The PvMSP-3β sequence of each isolate was determined and the polymorphic characteristics and effects of natural selec

SUBMITTER: Kang JM 

PROVIDER: S-EPMC3995521 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature