Altered profile of human gut microbiome is associated with cirrhosis and its complications.

ABSTRACT:

Background & aims

The gut microbiome is altered in cirrhosis; however its evolution with disease progression is only partly understood. We aimed to study changes in the microbiome over cirrhosis severity, its stability over time and its longitudinal alterations with decompensation.

Methods

Controls and age-matched cirrhotics (compensated/decompensated/hospitalized) were included. Their stool microbiota was quantified using multi-tagged pyrosequencing. The ratio of autochthonous to non-autochthonous taxa was calculated as the cirrhosis dysbiosis ratio (CDR); a low number indicating dysbiosis. Firstly, the microbiome was compared between controls and cirrhotic sub-groups. Secondly, for stability assessment, stool collected twice within 6months in compensated outpatients was an

SUBMITTER: Bajaj JS 

PROVIDER: S-EPMC3995845 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature