Protective effects of the polyphenol sesamin on allergen-induced T(H)2 responses and airway inflammation in mice.

ABSTRACT: Allergic asthma is a lifelong airway condition that affects people of all ages. In recent decades, asthma prevalence continues to increase globally, with an estimated number of 250,000 annual deaths attributed to the disease. Although inhaled corticosteroids and β-adrenergic receptor agonists are the primary therapeutic avenues that effectively reduce asthma symptoms, profound side effects may occur in patients with long-term treatments. Therefore, development of new therapeutic strategies is needed as alternative or supplement to current asthma treatments. Sesamin is a natural polyphenolic compound with strong anti-oxidative effects. Several studies have reported that sesamin is effective in preventing hypertension, thrombotic tendency, and neuroinflammation. However, it is still unknown

SUBMITTER: Lin CH 

PROVIDER: S-EPMC3996011 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature