The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.

ABSTRACT: A major goal of contemporary epilepsy research is the identification of therapies to prevent the development of recurrent seizures in individuals at risk, including those with brain injuries, infections, or neoplasms; status epilepticus; cortical dysplasias; or genetic epilepsy susceptibility. In this review we consider the evidence largely from preclinical models for the antiepileptogenic activity of a diverse range of potential therapies, including some marketed antiseizure drugs, as well as agents that act by immune and inflammatory mechanisms; reduction of oxidative stress; activation of the mammalian target of rapamycin or peroxisome proliferator-activated receptors γ pathways; effects on factors related to thrombolysis, hematopoesis, and angiogenesis; inhibition of 3-hydroxy-3-methyl

SUBMITTER: Kaminski RM 

PROVIDER: S-EPMC3996125 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature