African ancestry influences CCR5 -2459G>A genotype-associated virologic success of highly active antiretroviral therapy.

ABSTRACT:

Introduction

In a North American, HIV-positive, highly active antiretroviral therapy (HAART)-treated, adherent cohort of self-identified white and black patients, we previously observed that chemokine (C-C motif) receptor 5 (CCR5) -2459G>A genotype had a strong association with time to achieve virologic success (TVLS) in black but not in white patients.

Methods

Using 128 genome-wide ancestry informative markers, we performed a quantitative assessment of ancestry in these patients (n = 310) to determine (1) whether CCR5 -2459G>A genotype is still associated with TVLS of HAART when ancestry, not self-identified race, is considered and (2) whether this association is influenced by varying African ancestry.

Results

We found that the interaction between CCR5 -2459G>A genot

SUBMITTER: Cheruvu VK 

PROVIDER: S-EPMC3996453 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature