Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

ABSTRACT: Increased risk for autism spectrum disorders (ASD) is attributed to hundreds of genetic loci. The convergence of ASD variants have been investigated using various approaches, including protein interactions extracted from the published literature. However, these datasets are frequently incomplete, carry biases and are limited to interactions of a single splicing isoform, which may not be expressed in the disease-relevant tissue. Here we introduce a new interactome mapping approach by experimentally identifying interactions between brain-expressed alternatively spliced variants of ASD risk factors. The Autism Spliceform Interaction Network reveals that almost half of the detected interactions and about 30% of the newly identified interacting partners represent contribution from splicing vari

SUBMITTER: Corominas R 

PROVIDER: S-EPMC3996537 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature