Comparative effectiveness of oral diabetes drug combinations in reducing glycosylated hemoglobin.

ABSTRACT:

Aims

To provide evidence on the comparative effectiveness of oral diabetes drug combinations.

Methods

We performed a retrospective, observational cohort study of glycosylated hemoglobin change in outpatients newly exposed to dual- or triple-drug oral diabetes treatment.

Results

Adjusted response to a second drug added to metformin ranged from 0.85 to 1.21% glycosylated hemoglobin decline. Response to a third drug was smaller (0.53-0.91%). Higher baseline glycosylated hemoglobin was associated with larger response; sulfonylurea effectiveness declined over time; and thiazolidinediones were more effective in obese patients and women.

Conclusion

Observational data provide results qualitatively consistent with the limited available randomized data on diabetes drug e

SUBMITTER: Flory JH 

PROVIDER: S-EPMC3996558 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature