Apoptosis-related proteins and proliferation markers in the orbitofrontal cortex in major depressive disorder.

ABSTRACT:

Background

In major depressive disorder (MDD), lowered neural activity and significant reductions of markers of cell resiliency to degeneration occur in the prefrontal cortex (PFC). It is still unclear whether changes in other relevant markers of cell vulnerability to degeneration and markers of cell proliferation are associated with MDD.

Methods

Levels of caspase 8 (C8), X-linked inhibitor of apoptosis protein (XIAP), direct IAP binding protein with low pI (DIABLO), proliferating cell nuclear antigen (PCNA) and density of cells immunoreactive (-IR) for proliferation marker Ki-67 were measured in postmortem samples of the left orbitofrontal cortex (OFC) of subjects with MDD, and psychiatrically-normal comparison subjects.

Results

There was significant increase in C8,

SUBMITTER: Miguel-Hidalgo JJ 

PROVIDER: S-EPMC3996705 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature