ATP13A2 (PARK9) polymorphisms influence the neurotoxic effects of manganese.

ABSTRACT:

Introduction

A higher prevalence of individuals affected by Parkinsonism was found in Valcamonica, Italy. This may be related to ferro-alloy smelters in the area, releasing manganese (Mn) in the air, soil and water for about a century. There exists individual susceptibility for Mn neurotoxicity.

Aim

To analyse how polymorphism in genes regulating Mn metabolism and toxicity can modify neurophysiological effects of Mn exposure.

Materials and methods

Elderly (N=255) and adolescents (N=311) from Northern Italy were examined for neuromotor and olfactory functions. Exposure to Mn was assessed in blood and urine by atomic absorption spectroscopy and in soil by a portable instrument based on X-Ray fluorescence technology. Polymorphisms in the Parkinson-related gene ATPase typ

SUBMITTER: Rentschler G 

PROVIDER: S-EPMC3997180 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature