Epidemiological and molecular features of dengue virus type-1 in New Caledonia, South Pacific, 2001-2013.

ABSTRACT:

Background

The epidemiology of dengue in the South Pacific has been characterized by transmission of a single dominant serotype for 3-5 years, with subsequent replacement by another serotype. From 2001 to 2008 only DENV-1 was reported in the Pacific. In 2008, DENV-4 emerged and quickly displaced DENV-1 in the Pacific, except in New Caledonia (NC) where DENV-1 and DENV-4 co-circulated in 2008-2009. During 2012-2013, another DENV-1 outbreak occurred in NC, the third DENV-1 outbreak in a decade. Given that dengue is a serotype-specific immunizing infection, the recurrent outbreaks of a single serotype within a 10-year period was unexpected.

Findings

This study aimed to inform this phenomenon by examining the phylogenetic characteristics of the DENV-1 viruses in NC and other Pac

SUBMITTER: Dupont-Rouzeyrol M 

PROVIDER: S-EPMC3997821 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature