Genotype and diet shape resistance and tolerance across distinct phases of bacterial infection.

ABSTRACT:

Background

Host defense against pathogenic infection is composed of resistance and tolerance. Resistance is the ability of the host to limit a pathogen burden, whereas tolerance is the ability to limit the deleterious effects of a given pathogen burden. This distinction recognizes that the fittest host does not necessarily have the most aggressive immune system, suggesting that host-pathogen co-evolution involves more than an escalating arms race between pathogen virulence factors and host antimicrobial activity. How a host balances resistance and tolerance and how this balance influences the evolution of host defense remains unanswered. In order to determine how genotype-by-diet interactions and evolutionary costs of each strategy may constrain the evolution of host defense, we me

SUBMITTER: Howick VM 

PROVIDER: S-EPMC3997931 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature