CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population.

ABSTRACT:

Background

Neuromyelitis optica (NMO) is a serious inflammatory demyelinating disease (IDD), characterized by the inflammation and demyelination of optic nerves and spinal cords, which subsequently leads to the loss of function. In a previous genome-wide association study, cluster of differentiation 58 (CD58) region was found to be susceptible for the risk of multiple sclerosis (MS) in Caucasian, and the association between CD58 variants and MS was replicated in Americans. However, no study has been conducted to explore the possible association between CD58 and NMO yet. Thus, this study aimed to investigate the association of CD58 polymorphisms with the risk of NMO in a Korean population.

Methods

Using TaqMan assay, 6 single nucleotide polymorphisms (SNPs) were genotyped in

SUBMITTER: Kim JY 

PROVIDER: S-EPMC3998011 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature