Ambivalent role of pFAK-Y397 in serous ovarian cancer--a study of the OVCAD consortium.

ABSTRACT:

Background

Focal adhesion kinase (FAK) autophosphorylation seems to be a potential therapeutic target but little is known about the role and prognostic value of FAK and pFAK in epithelial ovarian cancer (EOC). Recently, we validated a gene signature classifying EOC patients into two subclasses and revealing genes of the focal adhesion pathway as significantly deregulated.

Methods

FAK expression and pFAK-Y397 abundance were elucidated by immunohistochemistry and microarray analysis in 179 serous EOC patients. In particular the prognostic value of phosphorylated FAK (pFAK-Y397) and FAK in advanced stage EOC was investigated.

Results

Multiple Cox-regression analysis showed that high pFAK abundance was associated with improved overall survival (HR 0.54; p = 0.034). FAK wa

SUBMITTER: Aust S 

PROVIDER: S-EPMC3998046 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature