Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis.

ABSTRACT:

Background

Efficacy of statins has been extensively studied, with much less information reported on their unintended effects. Evidence from randomized controlled trials (RCTs) on unintended effects is often insufficient to support hypotheses generated from observational studies. We aimed to systematically assess unintended effects of statins from observational studies in general populations with comparison of the findings where possible with those derived from randomized trials.

Methods

Medline (1998 to January 2012, week 3) and Embase (1998 to 2012, week 6) were searched using the standard BMJ Cohort studies filter. The search was supplemented with reference lists of all identified studies and contact with experts in the field. We included prospective studies with a sample

SUBMITTER: Macedo AF 

PROVIDER: S-EPMC3998050 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature