Childhood cognitive ability accounts for associations between cognitive ability and brain cortical thickness in old age.

ABSTRACT: Associations between brain cortical tissue volume and cognitive function in old age are frequently interpreted as suggesting that preservation of cortical tissue is the foundation of successful cognitive aging. However, this association could also, in part, reflect a lifelong association between cognitive ability and cortical tissue. We analyzed data on 588 subjects from the Lothian Birth Cohort 1936 who had intelligence quotient (IQ) scores from the same cognitive test available at both 11 and 70 years of age as well as high-resolution brain magnetic resonance imaging data obtained at approximately 73 years of age. Cortical thickness was estimated at 81 924 sampling points across the cortex for each subject using an automated pipeline. Multiple regression was used to assess associations b

SUBMITTER: Karama S 

PROVIDER: S-EPMC3998074 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature