Ontology highlight
ABSTRACT:
SUBMITTER: Ramakrishnan R
PROVIDER: S-EPMC3998104 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20140219 6
Cross-presentation is one of the main features of dendritic cells (DCs), which is critically important for the development of spontaneous and therapy-inducible antitumor immune responses. Patients, at early stages of cancer, have normal presence of DCs. However, the difficulties in the development of antitumor responses in patients with low tumor burden raised the question of the mechanisms of DC dysfunction. In this study, we found that, in differentiated DCs, tumor-derived factors blocked the ...[more]