Characterization of the SOS meta-regulon in the human gut microbiome.

ABSTRACT:

Motivation

Data from metagenomics projects remain largely untapped for the analysis of transcriptional regulatory networks. Here, we provide proof-of-concept that metagenomic data can be effectively leveraged to analyze regulatory networks by characterizing the SOS meta-regulon in the human gut microbiome.

Results

We combine well-established in silico and in vitro techniques to mine the human gut microbiome data and determine the relative composition of the SOS network in a natural setting. Our analysis highlights the importance of translesion synthesis as a primary function of the SOS response. We predict the association of this network with three novel protein clusters involved in cell wall biogenesis, chromosome partitioning and restriction modification, and we confirm bi

SUBMITTER: Cornish JP 

PROVIDER: S-EPMC3998124 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature