Modeling the impact of quadrivalent HPV vaccination on the incidence of Pap test abnormalities in the United States.

ABSTRACT:

Background

We present data on Pap test results and HPV prevalence from the HPV Sentinel Surveillance project, a multiyear surveillance project enrolling women from a diverse set of 26 clinics throughout the US from 2003 to 2005. We use mathematical modeling to illustrate the potential timing and magnitude of decreases in Pap test abnormalities in sexually transmitted disease (STD), family planning, and primary care clinics in the US as a result of HPV vaccination.

Methods

The probability of an abnormal Pap result was based on three factors: (1) infection with HPV 16/18, or both; (2) infection with high-risk HPV types other than HPV 16/18; and (3) infection with HPV 6/11, or both. We estimated the relative reduction in the probability of an abnormal Pap result over the first

SUBMITTER: Chesson HW 

PROVIDER: S-EPMC3998647 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature