A comparison of spatial analysis methods for the construction of topographic maps of retinal cell density.

ABSTRACT: Topographic maps that illustrate variations in the density of different neuronal sub-types across the retina are valuable tools for understanding the adaptive significance of retinal specialisations in different species of vertebrates. To date, such maps have been created from raw count data that have been subjected to only limited analysis (linear interpolation) and, in many cases, have been presented as iso-density contour maps with contour lines that have been smoothed 'by eye'. With the use of stereological approach to count neuronal distribution, a more rigorous approach to analysing the count data is warranted and potentially provides a more accurate representation of the neuron distribution pattern. Moreover, a formal spatial analysis of retinal topography permits a more robust comp

SUBMITTER: Garza-Gisholt E 

PROVIDER: S-EPMC3998654 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature