Quantitative tumor segmentation for evaluation of extent of glioblastoma resection to facilitate multisite clinical trials.

ABSTRACT: Standard-of-care therapy for glioblastomas, the most common and aggressive primary adult brain neoplasm, is maximal safe resection, followed by radiation and chemotherapy. Because maximizing resection may be beneficial for these patients, improving tumor extent of resection (EOR) with methods such as intraoperative 5-aminolevulinic acid fluorescence-guided surgery (FGS) is currently under evaluation. However, it is difficult to reproducibly judge EOR in these studies due to the lack of reliable tumor segmentation methods, especially for postoperative magnetic resonance imaging (MRI) scans. Therefore, a reliable, easily distributable segmentation method is needed to permit valid comparison, especially across multiple sites. We report a segmentation method that combines versatile region-of-i

SUBMITTER: Cordova JS 

PROVIDER: S-EPMC3998691 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature