Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism.

ABSTRACT: Nerves and vessels often run parallel to one another, a phenomenon that reflects their functional interdependency. Previous studies have suggested that neurovascular congruency in planar tissues such as skin is established through a "one-patterns-the-other" model, in which either the nervous system or the vascular system precedes developmentally and then instructs the other system to form using its established architecture as a template. Here, we find that, in tissues with complex three-dimensional structures such as the mouse whisker system, neurovascular congruency does not follow the previous model but rather is established via a mechanism in which nerves and vessels are patterned independently. Given the diversity of neurovascular structures in different tissues, guidance signals emana

SUBMITTER: Oh WJ 

PROVIDER: S-EPMC3998758 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature