Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state.

ABSTRACT:

Background

In a recent intervention study, the daily supplementation with 200 mg monomeric and oligomeric flavanols (MOF) from grape seeds for 8 weeks revealed a vascular health benefit in male smokers. The objective of the present study was to determine the impact of MOF consumption on the gene expression profile of leukocytes and to assess changes in DNA methylation.

Methodology/principal findings

Gene expression profiles were determined using whole genome microarrays (Agilent) and DNA methylation was assessed using HumanMethylation450 BeadChips (Illumina). MOF significantly modulated the expression of 864 genes. The majority of the affected genes are involved in chemotaxis, cell adhesion, cell infiltration or cytoskeleton organisation, suggesting lower immune cell adhesio

SUBMITTER: Milenkovic D 

PROVIDER: S-EPMC3998980 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature