Epidemiology of head and neck squamous cell cancer among HIV-infected patients.

ABSTRACT:

Background

HIV-infected individuals have a higher incidence of head and neck cancer (HNC).

Methods

Case series of 94 HIV-infected HNC patients (HIV-HNC) at 6 tertiary care referral centers in the US between 1991 and 2011. Clinical and risk factor data were abstracted from the medical record. Risk factors for survival were analyzed using Cox proportional hazard models. Human papillomavirus (HPV) and p16 testing was performed in 46 tumors. Findings were compared with Surveillance Epidemiology and End Results HNC (US-HNC) data.

Results

This study represents the largest HIV-HNC series reported to date. HIV-HNC cases were more likely than US-HNC to be male (91% vs. 68%), younger (median age, 50 vs. 62 years), nonwhite (49% vs. 18%), and current smokers (61% vs. 18%). Media

SUBMITTER: Dʼsouza G 

PROVIDER: S-EPMC3999230 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature