The development of the neural substrates of cognitive control in adolescents with autism spectrum disorders.

ABSTRACT:

Background

Autism spectrum disorders (ASDs) involve impairments in cognitive control. In typical development (TYP), neural systems underlying cognitive control undergo substantial maturation during adolescence. Development is delayed in adolescents with ASD. Little is known about the neural substrates of this delay.

Methods

We used event-related functional magnetic resonance imaging and a cognitive control task involving overcoming a prepotent response tendency to examine the development of cognitive control in young (ages 12-15; n = 13 with ASD and n = 13 with TYP) and older (ages 16-18; n = 14 with ASD and n = 14 with TYP) adolescents with whole-brain voxelwise univariate and task-related functional connectivity analyses.

Results

Older ASD and TYP showed reduced act

SUBMITTER: Solomon M 

PROVIDER: S-EPMC3999330 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature