Disrupted expected value signaling in youth with disruptive behavior disorders to environmental reinforcers.

ABSTRACT:

Objective

Youth with disruptive behavior disorders (DBD), including conduct disorder (CD) and oppositional defiant disorder (ODD), have difficulties in reinforcement-based decision making, the neural basis of which is poorly understood. Studies examining decision making in youth with DBD have revealed reduced reward responses within the ventromedial prefrontal cortex/orbitofrontal cortex (vmPFC/OFC), increased responses to unexpected punishment within the vmPFC and striatum, and reduced use of expected value information in the anterior insula cortex and dorsal anterior cingulate cortex during the avoidance of suboptimal choices. Previous work has used only monetary reinforcement. The current study examined whether dysfunction in youth with DBD during decision making extended to env

SUBMITTER: White SF 

PROVIDER: S-EPMC3999439 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature