Detecting a clinically meaningful change in tic severity in Tourette syndrome: a comparison of three methods.

ABSTRACT:

Objective

To compare three statistical strategies for classifying positive treatment response based on a dimensional measure (Yale Global Tic Severity Scale [YGTSS]) and a categorical measure (Clinical Global Impression-Improvement [CGI-I] scale).

Method

Subjects (N=232; 69.4% male; ages 9-69years) with Tourette syndrome or chronic tic disorder participated in one of two 10-week, randomized controlled trials comparing behavioral treatment to supportive therapy. The YGTSS and CGI-I were rated by clinicians blind to treatment assignment. We examined the percent reduction in the YGTSS-Total Tic Score (TTS) against Much Improved or Very Much Improved on the CGI-I, computed a signal detection analysis (SDA) and built a mixture model to classify dimensional response based on the c

SUBMITTER: Jeon S 

PROVIDER: S-EPMC3999642 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature