Translational control of JunB, an AP-1 transcription factor, in activated human endothelial cells.

ABSTRACT: Stimulated endothelial cells (EC) assume an activated phenotype with pro-inflammatory and prothrombotic features, requiring new gene and protein expression. New protein synthesis in activated EC is largely regulated by transcriptional events controlled by a variety of transcription factors. However, post-transcriptional control of gene expression also influences phenotype and allows the cell to alter protein expression in a faster and more direct way than is typically possible with transcriptional mechanisms. We sought to demonstrate that post-transcriptional control of gene expression occurs during EC activation. Using thrombin-activated EC and a high-throughput, microarray-based approach, we identified a number of gene products that may be regulated through post-transcriptional mechanism

SUBMITTER: Schmid DI 

PROVIDER: S-EPMC3999827 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature